越南的成年人患有腹时使用的Clostridioides (Clostridium) difficile
Peng An Khun1, Long Duc Phi2, Huong Thi Thu Bui3
1School of Biomedical Sciences, The University of Western Australia, Western Australia, Australia.
Anaerobe
|May 27, 2023
概括
困难 Clostridioides 感染 (CDI) 在越南成年人中常见于腹,显示多药耐药性的高率. 临床评估至关重要,以区分CDI与殖民.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 困难类克洛斯特里迪奥伊德会引起与抗微生物药物相关的腹,临床表现各异.
- 关于越南C. difficile感染 (CDI) 的数据有限.
- 这项研究涉及越南成年人中C. difficile的流行病学,分子特征和抗菌敏感性.
研究的目的:
- 评估越南成年腹患者中C. difficile的患病率.
- 为了描述C. difficile分离物的分子流行病学.
- 为了确定C. difficile的抗微生物敏感性模式.
主要方法:
- 从越南北部的成年患者 (≥17岁) 收集了腹便样本.
- 样品经过C. difficile培养,毒素基因分析和PCR核型定型.
- 对隔离的C. difficile菌株进行了抗微生物敏感性测试.
主要成果:
- 困难菌的流行率为15.1% (31/205),其中有9.8%的毒性和6.3%的非毒性分离物.
- 确定了18种已知和1种新型核糖型,其中RT 012是最常见的.
- 对克林达胺素 (78.8%),红色胺素 (51.5%),四环素 (27.3%) 和利法西明 (6.1%) 观察到高耐药率. 在27.3%的隔离物中发现了多重药物耐药性.
结论:
- 在越南成年人腹中,C. difficile和多种药物耐药性的患病率特别高.
- 区分CDI和无症状殖民需要仔细的临床评估.
- 进一步的监测和抗微生物药物管理是合理的.
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