在非常早产的婴儿中,母亲的产前风险现象和神经行为结果
Marie Camerota1, Elisabeth C McGowan2, Brian S Carter3
1Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI; Department of Pediatrics, Women and Infants Hospital, Providence, RI.
The Journal of pediatrics
|May 27, 2023
概括
母亲产前风险因素与非常早产婴儿的神经行为问题有关. 这一发现有助于识别需要早期干预的新生儿,以获得更好的发育结果.
科学领域:
- 新生儿研究新生儿研究
- 发育儿科 发育儿科
- 孕产妇和胎儿的医学
背景情况:
- 非常早产的婴儿 (<30周怀孕) 面临着重大的神经发育挑战.
- 产前风险因素可以影响婴儿的神经行为结果.
- 早期发现有风险的婴儿对于及时干预至关重要.
研究的目的:
- 为了确定产前风险表型是否与非常早产婴儿的神经行为障碍相关.
- 评估新生儿重症监护室 (NICU) 出院和24个月的随访时的神经行为结果.
- 确定与婴儿神经发育不良相关的特定母亲风险因素.
主要方法:
- 这项研究分析了新生儿神经行为和非常早产婴儿结果 (NOVI) 研究中的704名怀孕30周以下的婴儿的数据.
- 孕产妇产前风险表型根据24个身体和心理健康因素进行了分类.
- 婴儿神经行为被评估使用NICU网络神经行为尺度在出院和贝利尺度婴幼儿发育和儿童行为检查表在24个月.
主要成果:
- 在心理风险组中的母亲的孩子显示出新生儿神经行为失调的风险增加 (OR,2.04) 和24个月,严重的运动延迟 (OR,3.80) 和外部化问题 (OR,2.54).
- 身体风险组中的母亲的孩子在24个月后更有可能出现严重的运动延迟 (OR,2.70).
- 这些关联与低风险组的母亲生下的婴儿进行了比较.
结论:
- 高风险的孕产妇产前表型与非常早产婴儿的神经行为障碍显著相关.
- 识别这些孕产妇的风险因素可以帮助早期检测易受不良神经发育轨迹的新生儿.
- 这项研究强调了产前健康在塑造婴儿长期结果方面的重要性.
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