感冒对中国南京成年人血红素的短期影响:分布式滞后效应分析
Bei-Jing Cheng1, Tian-Lin Li1, Hui Li1
1Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China.
The Science of the total environment
|May 27, 2023
概括
感冒症状显著增加了血液中血红素水平,这是心血管疾病的血液指标,长达26天. 女性和老年人更容易受到这些影响.
科学领域:
- 环境健康 环境健康
- 心血管流行病学心血管流行病学
- 血液学 血液学 血液学
背景情况:
- 以前的研究将感冒与心血管疾病联系在一起.
- 潜在的生物机制需要进一步阐明.
- 血红素是与心血管疾病风险相关的关键血液指标.
研究的目的:
- 调查寒冷时期对血红素水平的短期影响.
- 了解寒冷期暴露和血位数变化之间的时间关系.
主要方法:
- 利用了来自中国南京的50538名参与者的健康检查数据 (2019-2021).
- 定义寒冷时期是每日平均气温至少连续两天低于第三或第五百分位.
- 采用线性混合效应和分布式滞后非线性模型来分析寒冷和血红素之间的关联.
主要成果:
- 感冒症状显示,从0至26天的滞后时间,血红素与显著的积极关联.
- 寒冷时期对血红素的累积影响在各种滞后期内仍然显著.
- 观察到血红素的增加,寒冷的咒语 (T 平均三分之一) 滞后0-27天,与3.71%的增加 (95% CI:3.06,4.35) 相关.
- 在女性和50岁及以上的个体中观察到更强烈的效应.
结论:
- 感冒对血红素水平产生了即时和长时间的影响,持续时间长达26天.
- 50岁以上的女性和个人对感冒诱导的血红素变化表现出高度敏感.
- 这些发现为暴露于寒冷时期的心血管影响提供了新的见解.
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