乳房切除术后强度调节质子疗法:5年瘤和患者报告的结果
Robert W Gao1, Trey C Mullikin2, Khaled A Aziz1
1Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
概括
乳腺切除术后强度调节质子疗法 (IMPT) 放射治疗显示出优异的瘤治疗结果和患者报告的生活质量. 与传统方法相比,这种先进的辐射技术显示出有利的并发症率.
科学领域:
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
- 在瘤学瘤学.
背景情况:
- 乳腺切除术后的放射治疗 (PMRT) 对于减少高风险乳腺癌患者的局部区域复发至关重要.
- 现代进步旨在提高治疗效率,同时尽量减少对风险器官和皮肤的毒性.
- 强度调节质子疗法 (IMPT) 提供精确的剂量输送,可能提高结果和耐受性.
研究的目的:
- 为了评估瘤学,医生评估和患者报告的结果 (PROs),在皮肤节省多领域优化IMPT后进行PMRT.
- 评估IMPT在同质治疗的乳腺癌患者队列中的安全性和有效性.
主要方法:
- 在2015-2019年期间对127名患者进行单边治疗,治疗意图的IMPT PMRT治疗的回顾性审查.
- 严格的剂量限制适用于危险的皮肤和器官.
- 分析了多个时间点的五年瘤结果和潜在的患者报告结果 (PRO).
主要成果:
- 观察到优异的5年局部区域控制 (98.4%) 和整体存活率 (87.9%).
- 急性 (4% 3级) 和晚期 (3事件) 毒性低,没有心脏或肺部不良事件.
- 皮肤质量和功能的变化很小,重建并发症率很高 (10%).
结论:
- 乳腺切除术后的IMPT,具有严格的剂量限制,可以实现出色的瘤学结果和患者报告的结果.
- 皮肤,胸壁和重建的并发症率与历史的质子和光子疗法数据相比较有利.
- 需要对PMRT的IMPT进行进一步的多机构调查,重点是优化规划技术.
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