深度与活性性结肠炎中C-反应蛋白增加有关
P Rivière1, A Le Chevillier2, A Rullier3
1CHU de Bordeaux, Centre Medico-chirurgical Magellan, Hôpital Haut-Lévêque, Gastroenterology department, Université de Bordeaux, INSERM CIC 1401, Bordeaux, France; Program in Infectious Diseases and Immunity in Global Health, Research Institute of the McGill University Health Centre, Montreal, Québec, Canada.
概括
高C反应蛋白 (CRP) 水平强烈表明性结肠炎 (UC) 患者的深. 这一发现可以指导严重UC病例的治疗决策.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病研究研究
- 临床生物标志物研究研究
背景情况:
- 反应蛋白 (CRP) 是诊断和预测严重性结肠炎 (UC) 治疗反应的关键指标.
- 了解CRP水平和深度之间的关系对于有效的患者管理至关重要.
研究的目的:
- 调查C反应性蛋白 (CRP) 水平升高与性结肠炎 (UC) 患者深层的存在之间的相关性.
主要方法:
- 使用了多中心前性队列研究和回顾性切除队列,在2012年至2019年期间招募了活跃UC患者.
- 数据分析的重点是将CRP水平 (分类为<30 mg/L,30-100 mg/L和>100 mg/L) 与深度的存在相关联.
主要成果:
- 在前性队列 (41名患者) 中,在22%的患者中发现了深,在较高的CRP水平和深之间观察到显著的关联 (p=0.006).
- 追溯队列 (46名患者) 显示出类似的趋势,其中67%患有深层,与CRP升高有很强的相关性 (p=0.001).
- 在两个队列中,CRP水平>100 mg/L显示了深的高积极预测值 (80%和100%).
结论:
- 升高的C-反应蛋白 (CRP) 作为可靠的替代标记物,用于识别性结肠炎 (UC) 患者的深.
- 高水平的CRP和深层的存在都是可能影响急性严重UC医疗选择的重要因素.
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