怀孕对多功能IgG和记忆B细胞对Tdap免疫接种反应的影响
Martin Taton1, Fabienne Willems1, Cyprien Widomski1
1Institute for Medical Immunology and ULB Center for Research in Immunology (U-CRI), Faculty of Medicine, Université libre de Bruxelles (ULB), Lennik Rd. 808, Anderlecht 1070, Brussels, Belgium.
Vaccine
|May 27, 2023
概括
孕妇在怀孕期间接种Tdap疫苗可以有效地保护新生儿. 孕妇具有强大的IgG和B细胞记忆反应,与非孕妇相比,确保有效的抗体转移到胎儿.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 用Tdap疫苗进行孕产妇免疫接种对于新生儿对咳的保护至关重要.
- 与怀孕相关的免疫学转变可能会影响疫苗反应.
- 关于孕妇对Tdap的IgG和B细胞记忆反应的数据有限.
研究的目的:
- 为了评估怀孕对Tdap疫苗接种的幽默性免疫反应的影响.
- 在母体Tdap免疫接种后,特征IgG质量和B细胞记忆生成.
主要方法:
- 在孕妇 (n=42) 与非孕妇 (n=39) 中比较幽默免疫反应.
- 在疫苗接种前和后评估血清百日咳和病特异性IgG,IgG子类,Fc介导的效应因子功能和B细胞记忆频率.
- 在母体和带血液中分析了抗体和效应器功能水平.
主要成果:
- 孕妇和非孕妇在Tdap疫苗接种后的IgG和IgG亚类水平相似.
- 孕妇产生多功能IgG,促进补充体沉积和细胞化.
- 在两组中都观察到类似的百日咳和特异性记忆B细胞的频率.
- 带血表现出更高的疫苗特异性IgG和Fc介导的效应因子功能,而不是母亲的血液.
结论:
- 怀孕不会影响效应IgG或B细胞对Tdap免疫接种反应的质量.
- 多功能母体IgG抗体通过胎盘有效地转移到胎儿.
- 孕产妇Tdap疫苗接种通过强烈的孕产妇反应和胎盘转移在新生儿中引起保护性免疫力.
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