人类白细胞抗原免疫在输血依赖的摩洛哥患者与β-thalassemia主要:流行率和风险因素
Sanae Ouadghiri1, Kaoutar El Morabit2, Naoual Elansari3
1Blood Transfusion, Ibn Sina University Hospital, Rabat, Morocco; Faculty of Medicine and Pharmacy, Mohamed V University, Rabat, Morocco.
接受定期输血的Beta-thalassemia重症患者面临着开发人类白细胞抗原 (HLA) 抗体的高风险. 这项研究确定了HLA DRB1*11作为摩洛哥患者对这种合免疫的保护因素.
科学领域:
- 免疫遗传学 免疫遗传学
- 血液学 血液学 血液学
- 输血医学 输血医学
背景情况:
- 大型β-thalassemia需要频繁的输血,增加了与免疫接种的风险.
- 艾洛抗体,特别是人类白细胞抗原 (HLA) 抗体,在输血管理中构成重大挑战.
- 了解HLA配免疫对于改善beta-thalassemia患者的输血策略至关重要.
研究的目的:
- 在摩洛哥的β-thalassemia主要患者中研究HLA配免疫.
- 为了将HLA抗体的发展与输血史和人口因素相关联.
- 为了确定与非免疫化风险相关的特定HLA等位基因.
主要方法:
- 这项研究涉及53名摩洛哥儿科患者,他们患有β-thalassemia major.
- 使用Luminex技术选了HLA配抗体.
- 使用序列特异性原始体 (PCR-SSP) 进行了HLA基因型鉴定.
主要成果:
- 50.9%的患者检测出HLA抗体呈阳性,其中59.3%具有I类和II类抗体.
- 在未免疫患者中,HLA DRB1*11等位基因显著更频繁 (34.6%与0%,p=0.001).
- 女性患者 (72.4%) 和接受超过300个红细胞单位 (66.7%) 的患者显示HLA免疫率更高.
结论:
- 输血依赖性β-thalassemia主要患者有风险发展HLA抗体,尽管白血病减少的红细胞输血.
- 在这个患者队列中,HLA DRB1*11等位基因似乎能提供对HLA配免疫的保护.
- 人口因素和输血负载与β-thalassemia中的HLA配免疫有关.
更多相关视频
07:18HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL
Published on: April 11, 2011
11:55Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
Published on: March 14, 2011
相关概念视频
Rh Blood Group
Blood Transfusion
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
Blood Transfusion and Agglutination
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Blood Types
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
Kidney Transplant I: Introduction
