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基于DNA的neoepitope疫苗接种诱导了瘤控制在syngeneic小鼠模型

Nadia Viborg^1,2, Michail Angelos Pavlidis¹, Marina Barrio-Calvo¹

¹Evaxion Biotech, Hørsholm, Denmark.

|May 27, 2023

概括

在小鼠模型中,Neoepitope DNA疫苗接种有效地产生抗瘤免疫力和持久的T细胞反应. 将DNA疫苗与免疫检查点抑制剂结合起来,可以增强针对个性化癌症免疫治疗的抗瘤效果.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
疫苗学疫苗学疫苗学

背景情况:

来自瘤突变的新表位细胞是癌症免疫治疗的有希望的标.
在临床前和临床研究中,通过癌症疫苗传递新表皮质显示出潜在的潜力.

研究的目的:

评估等离子体DNA在诱导新表位细胞免疫性和抗瘤效果方面的有效性.
在同基因小鼠癌症模型中评估新史基因DNA疫苗接种.

主要方法:

在CT26和B16F10小鼠癌症模型中进行了新形DNA疫苗接种.
监测血液,脏和瘤中的特异性T细胞反应.
研究了CD4+和CD8+T细胞在瘤生长抑制中的作用.
评估了与免疫检查点抑制剂的联合治疗.

主要成果:

在这两种模型中,Neoepitope DNA疫苗接种诱导了显著的抗瘤免疫力.
在接种疫苗后观察到长期的新表位特异性T细胞反应.
CD4+和CD8+T细胞反应对于阻碍瘤生长至关重要.
组合疗法表现出添加性抗瘤作用,表现优于单一疗法.

结论:

新位DNA接种疫苗是诱导抗瘤免疫力的可行策略.
DNA疫苗接种和免疫检查点抑制的结合提供了一种优越的治疗方法.
DNA 疫苗接种平台可适应基于新位基的个性化癌症免疫疗法.

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