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压力控制和脑中的区域性炎症反应:由底侧杏仁体调节
Austin M Adkins1,2,3, Emily M Colby1,2,3, Woong-Ki Kim2,4
1Sleep Research Laboratory, Eastern Virginia Medical School, P.O. Box 1980, Norfolk, VA, 23507, USA.
Journal of neuroinflammation
|May 27, 2023
概括
压力可控性影响大脑炎症,底侧杏仁体 (BLA) 在海马和中部前额皮层调节这些影响. 这突出了神经回路调节压力诱导的免疫反应.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 压力研究 压力研究
背景情况:
- 神经精神病和神经退行性疾病与压力诱导的免疫失调有关.
- 压力经历,像足震,根据可控性 (可逃脱与不可逃脱) 不同地改变大脑炎症基因表达.
- 底侧杏仁体 (BLA) 影响压力和恐惧记忆,影响睡眠和免疫反应.
研究的目的:
- 在压力期间调查BLA在调节海马体 (HPC) 和中间前额皮质 (mPFC) 中区域炎症反应中的作用.
- 确定光遗传学操纵BLA活性如何影响压力诱导的基因表达特征.
- 探索潜在的神经电路压力因素的可控性及其对大脑炎症的影响.
主要方法:
- 在雄性C57BL/6小鼠中,利用了带有可逃脱 (ES) 和不可逃脱 (IS) 足震应激的束式穿箱范式.
- 在应激暴露期间以光遗传学方式刺激或抑制BLA.
- 在HPC和mPFC中使用NanoString®鼠标神经炎症面板分析基因表达.
主要成果:
- ES和IS的压力诱导了区别的区域基因表达,并激活了HPC和mPFC中的炎症途径.
- BLA操纵 (激发或抑制) 改变了这些由压力引起的炎症差异.
- 研究结果表明,BLA会影响区域性炎症反应 (副炎症) 对可控和无法控制的压力.
结论:
- 压力可控性显著影响大脑的免疫反应,称为"副炎症".
- 在应对不同类型的压力时,BLA在HPC和mPFC中的区域性副炎症中起着关键作用.
- 这项研究表明神经电路水平调节压力诱导的炎症,提供了对差异性压力结果的见解.
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