胃癌治疗:最近的进展和未来的前景
Wen-Long Guan1,2, Ye He1,2, Rui-Hua Xu3,4
1Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, People's Republic of China.
Journal of hematology & oncology
|May 27, 2023
概括
胃癌 (GC) 的全身治疗方法正在进步,化疗,向疗法和免疫疗法显示出有前途. 生物标志物驱动的方法个性化治疗,以获得可切除和转移性GC的更好的结果.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 胃癌 (GC) 是一种常见的恶性瘤,通常在晚期被诊断出来.
- 微妙的早期症状和低查率有助于晚期诊断.
- 对GC的全身疗法最近取得了重大进展.
研究的目的:
- 审查胃癌全身治疗的研究进展.
- 讨论基于分子生物标志物的当前个性化治疗策略.
- 介绍胃癌治疗的未来前景.
主要方法:
- 对胃癌全身疗法的最新研究进行系统审查.
- 分析化疗,向治疗和免疫治疗方面的进展.
- 基于生物标志物进行个性化治疗的分类的评估.
主要成果:
- 周围手术化学疗法是可切除的GC的标准.
- 针对性治疗和免疫疗法正在为外科手术前/辅助设置进行研究.
- 免疫疗法和生物标志物导向疗法最近在转移性GC方面取得了进展.
- 像PD-L1,MSI和HER2这样的分子生物标志物有助于免疫治疗和向治疗的患者分层.
结论:
- 针对胃癌的个性化治疗策略正在出现.
- 分子诊断对于描述GC和识别治疗点至关重要.
- 对全身治疗和向治疗的持续研究有望改善患者的治疗结果.
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