睡眠障碍与指数和并发性精神障碍以及精神药物相关
Ray M Merrill1, McKay K Ashton2, Emily Angell2
1Department of Public Health, College of Life Sciences, Brigham Young University, Provo, UT, 84602, USA. Ray_Merrill@byu.edu.
Annals of general psychiatry
|May 27, 2023
概括
精神障碍显著增加失眠和睡眠呼吸暂停的风险,尤其是在并发症时. 某些精神药物与这些睡眠障碍有关.
科学领域:
- 精神病学和睡眠医学
- 药理学和治疗学 药理学和治疗学
- 流行病学和公共卫生.
背景情况:
- 众所周知,精神障碍与睡眠障碍有积极的关联.
- 伴随性精神健康状况和精神药物使用对睡眠障碍的具体影响需要进一步调查.
研究的目的:
- 探索伴随性精神障碍对精神障碍和睡眠障碍之间关联的缓解影响.
- 调查特定的精神药物和睡眠障碍之间的相关性,调整为心理健康状况.
主要方法:
- 从2016年至2020年,利用Deseret互惠福利管理员 (DMBA) 的医疗索赔数据进行了回顾性队列研究.
- 纳入标准包括18-64岁的个人.
- 提取的数据包括精神障碍,精神药物使用和人口统计信息.
主要成果:
- 11.7%的队列提出了睡眠障碍的索赔 (失眠2.2%,睡眠呼吸暂停9.7%).
- 精神障碍,特别是双相情感障碍和精神分裂症,与失眠和睡眠呼吸暂停有显著的积极关联.
- 镇静剂 (非巴比酸盐) 和精神兴奋剂被确定为关键的精神药物类别,与失眠和睡眠呼吸暂停的增加有关.
结论:
- 精神障碍与失眠和睡眠呼吸暂停之间存在着强烈的正相关性,并由并发症放大.
- 双极性障碍和精神分裂症与失眠最为密切相关,而双极性障碍和抑郁症与睡眠障碍最为密切相关.
- 特定的精神药物,主要是镇静剂和精神兴奋剂,与焦虑,抑郁或双相情感障碍患者的失眠和睡眠呼吸暂停率较高有关.
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