用支持的植入物用于预防和治疗受损宿主手术部位感染:一项前性研究
Toshiharu Shirai1,2, Hiroyuki Tsuchiya3, Ryu Terauchi4
1Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-Ku, Kyoto, 602-8566, Japan. shi-ra-e@koto.kpu-m.ac.jp.
Journal of orthopaedic surgery and research
|May 27, 2023
概括
植入物的涂层显著减少了骨科手术患者的手术部位感染 (SSI),特别是那些健康状况不佳的患者. 这种创新方法可以更好地控制术后感染,特别是在脊柱修复手术中.
科学领域:
- 整形外科手术 整形外科手术
- 生物材料科学是生物材料的科学.
- 传染病研究传染病研究.
背景情况:
- 手术部位感染 (SSI) 是骨科植入程序的一个重要并发症.
- 植入物的涂层是为了减轻植入物相关的感染而开发的.
- 一项前性临床研究旨在评估支持植入物的疗效和安全性.
研究的目的:
- 评估涂层植入物在预防和治疗骨科感染方面的有效性.
- 评估与支持植入物相关的失败率和失败模式.
- 确定健康状况不佳或活跃感染的患者的潜在益处.
主要方法:
- 一项前性观察性研究 (IV级证据),从2008年7月至2017年7月,涉及653名患者.
- 患者接受了含的植入物以预防感染 (477名患者) 或治疗 (176名患者).
- 随访时间平均为41.7个月,分析植入物失败模式,包括软组织失败,无菌松动,结构失败,感染和瘤进展.
主要成果:
- 整体植入器失效率为26.3%,机械失效包括101例,非机械失效71例.
- 感染的总发病率为6.8%,预防感染率为3.7%,治疗感染率为15.3%.
- 使用涂层仪器进行的脊柱手术显示,11例治疗的SSI病例中,再感染率为0%.
结论:
- 与现有文献相比,支持的植入物显示出令人满意的故障模式.
- 受损宿主中的低感染率表明,手术后感染控制得到了改善.
- 涂层植入物对于需要一阶段修复手术的脊柱感染非常有效.
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