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介质干细胞 (MSC) 在神经退行性疾病中的应用:历史,发现和未来的挑战

Negin Biglari¹, Amir Mehdizadeh², Mahsa Vafaei Mastanabad³

¹Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Pathology, research and practice

|May 28, 2023

概括

来自各种来源的介质干细胞通过影响神经质特异化途径,显示出治疗神经退行性疾病的潜力. 研究比较脂肪细胞,带和骨髓来源的治疗应用.

科学领域:

干细胞生物学干细胞生物学
神经科学是一个神经科学.
再生医学是一种再生医学.

背景情况:

介质细胞干细胞 (MSC) 在治疗潜力方面得到了广泛的研究.
MSCs可以来自各种组织,包括脂肪组织,胎儿带和骨髓.
像帕金森氏症,阿尔茨海默氏症和多发性硬化症这样的神经系统疾病是重要的治疗目标.

研究的目的:

为了比较和对比不同的介质干细胞来源.
研究MSCs在治疗神经退行性疾病方面的潜力.
探索涉及神经质物种化中的分子通路.

主要方法:

来自脂肪细胞,胎儿带组织和骨髓的MSCs的比较分析.
研究不同MSC来源的细胞特征.
在神经质分化中的分子信号通路的探索.

主要成果:

从不同来源的MSC中识别不同的细胞特征.
证据表明MSCs有可能修改神经退行性疾病过程.
对神经质物种化至关重要的分子通路的阐明.

结论:

不同的MSC来源具有与治疗应用相关的独特特征.
MSCs有望开发神经退行性疾病的新疗法.
对MSC介导的分子机制的进一步研究有必要进行临床转化.

关键词:

AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD ADD was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was 这就是ALS.在MSMSMSMSMSMSMSMSMSMSMS中,我们可以看到多国中心的MSCs.神经退行性疾病神经退行性疾病警方警方警方警方

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Mesenchymal Stem Cells

Mesenchymal Stem Cells

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