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灰色物质与基本震中的反性软征兆相关

Dana Brinker¹, Oliver Granert¹, Felix Gövert¹

¹Department of Neurology, UKSH, Christian-Albrechts University Kiel, Germany.

Parkinsonism & related disorders

|May 28, 2023

概括

患有 dystonic 症状的基本震患者表现出大脑结构变化,特别是在基底和额叶皮层. 这些变化表明与 dystonia 有联系,与没有这些迹象的基本震不同.

科学领域:

神经成像是一种神经成像.
运动障碍运动障碍
神经学神经学

背景情况:

基本震 (ET) 经常呈现出可疑的 dystonic 迹象.
与没有 (ET-ds) 或有明显的 dystonia (TAWD) 患者相比,ET患者具有 dystonic 症状 (ET + ds) 的大脑结构差异尚不清楚.

研究的目的:

这项研究调查了ET患者大脑中的灰质变化,这些患者表现出 dystonic 迹象.

主要方法:

使用基于voxel的形态测量 (VBM) 分析3TMRI扫描.
在68名ET患者 (ET-ds,ET+ds,TAWD) 和42名健康对照中评估了灰质变化.
回归分析探讨了与临床震参数的相关性.

主要成果:

与对照组和ET-ds相比,在ET + ds和TAWD组观察到右状核中的灰质增加.
ET + ds 患者在中额头环中皮质灰质增加.
在ET + ds中,状核缩与疾病的严重程度和持续时间相关.

结论:

患有 dystonic 症状的 ET 患者表现出类似于明显 dystonia (TAWD) 的大脑结构性改变.
研究结果表明,ET + ds中的基底状皮质环涉及ET + ds,这表明潜在的病理生理重叠与TAWD而不是纯ET.

关键词:

消极性震的震.基本的震震.基本震加上基本震.灰色物质的变化灰色物质的变化这就是VBM的VBM.

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