在帕金森病患者中,人类大脑网络层次的功能障碍导致步态结
Xiuhang Ruan1, Xiaofei Huang1, Yuting Li1
1Department of Radiology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China.
Parkinsonism & related disorders
|May 28, 2023
概括
大脑网络层次结构在帕金森病中被破坏,导致步态结 (PD-FOG). 这些变化与步态问题和结步态的严重程度相关,为FOG的神经基础提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 系统神经科学 系统神经科学
- 大脑网络组织组织大脑网络组织
背景情况:
- 大脑网络表现出层次组织.
- 帕金森病与步态结 (PD-FOG) 的网络层次结构中断尚未得到充分理解.
- 在PD-FOG中改变大脑网络层次的临床相关性需要调查.
研究的目的:
- 在PD-FOG中探索大脑网络层次结构的变化.
- 调查这些网络层次变化的临床相关性.
- 提供FOG底层神经机制的证据.
主要方法:
- 使用Connectome梯度分析来描述大脑网络层次结构.
- 分析的组包括PD-FOG,PD没有FOG (PD-NFOG) 和健康对照 (HC).
- 网络梯度值在各组之间进行了比较,并检查了与临床尺度的关系.
主要成果:
- 与PD-NFOG相比,PD-FOG的突出/腹部注意网络-A (SalVentAttnA) 梯度较低.
- 两个PD子组的默认模式网络-C梯度都比HC低.
- 减少SalVentAttnA梯度与PD-FOG中更严重的步态,跌倒风险和结步态相关.
结论:
- 在PD-FOG中,大脑网络层次结构受到干扰.
- 这种网络功能障碍与冷步行的严重程度有关.
- 这项研究为FOG的神经机制提供了新的见解.
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