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HI-FIVE试验:使用4维68Ga通风- perfusion正子发射断层扫描-计算机断层扫描以避免局部高级非小细胞肺癌的功能性肺癌的前性试验

Nicholas W Bucknell¹, Nicholas Hardcastle², Beverley Woon³

¹Division of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.

International journal of radiation oncology, biology, physics

|May 28, 2023

概括

使用68通风透PET/CT的功能性肺避开辐射疗法是可行的. 这种技术成功地减少了非小细胞肺癌患者的肺辐射剂量和毒性.

科学领域:

辐射瘤学辐射瘤学
核医学就是核医学.
肺部医学肺部医学

背景情况:

功能性肺部回避 (FLA) 放射治疗旨在通过节省功能性肺部区域来最大限度地降低毒性.
准确的功能性肺部成像对于有效的FLA实施至关重要.

研究的目的:

报告第一个评估FLA的前性试验的结果,使用4维68通风透正子发射断层扫描-计算机断层扫描 (Ga-4D-V/Q PET/CT).

主要方法:

这项研究包括了患有第三期非小细胞肺癌的患者,这些患者接受了激进化学辐射.
使用Ga-4D-V/Q PET/CT来确定功能性肺体积,用于生成FLA计划.
可行性标准包括功能性肺剂量和可接受的心脏剂量的显著降低.

主要成果:

18名患者完成了用FLA进行化学辐射治疗,其中15人符合可行性标准.
FLA实现了功能性平均肺剂量平均减少12.4%,功能性V20Gy.减少22.9%.
在12个月后,总生存率为83%,无进展生存率为50%,生活质量稳定.

结论:

Ga-4D-V/Q PET/CT是一种可行的成像方法,可以在放射治疗中避免功能性肺部.
这种方法对减少肺癌患者的毒性有希望.

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