带有心室辅助器件的患者中驱动线出口部位的细菌病原体的动力学:一个前性,观察性,单中心队列研究
Melissa Pitton1, Luca G Valente2, Simone Oberhaensli3
1Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Graduate School for Cellular and Biomedical Sciences (GCB), University of Bern, Bern, Switzerland.
概括
在左心室辅助装置 (LVAD) 驱动线出口点的细菌殖民是常见的,可能导致驱动线感染 (DLI). 这项研究追踪了细菌的动态,揭示了殖民化可以先于感染.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 心血管外科心血管外科
背景情况:
- 驱动线感染 (DLI) 是左心室辅助器件 (LVAD) 患者的常见并发症.
- 从细菌殖民到临床DLI的转变在驱动线出口处仍然没有研究过.
- 了解这些动态对于预防LVAD相关感染至关重要.
研究的目的:
- 为了研究LVAD患者在驱动线输出部位的细菌殖民的动态.
- 为了深入了解DLI的病原性.
- 为了识别参与殖民和感染的细菌物种.
主要方法:
- 一个前性的,观察性的,单中心的队列研究.
- 在LVAD患者的驱动线出口部位的系统抽样.
- 细菌分离物的识别和全基因组测序.
主要成果:
- 驱动线出口处的细菌殖民是常见的 (37.8%),通常没有感染的临床迹象.
- 在研究期间,超过48%的患者至少发生了一次DLI事件.
- 基因组分析证实了细菌的持久性,并在某些情况下确定了从殖民到感染的过渡.
结论:
- 在LVAD驱动线出口处的细菌殖民是DLI的常见前体.
- 这项研究为DLI病原和细菌动态提供了新的见解.
- 这些发现突出了医院获得的多种耐药细菌获取和病原体传播的潜力.
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