暴露于环境空气污染和年轻人血液端粒变化之间的关联:一项重复测量研究
Xiaojing Zhu1, Zhigang Li1, Ziye Wang1
1State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China.
Chemosphere
|May 28, 2023
概括
短期暴露于臭氧 (O3) 会缩短端粒长度 (TL),但端粒酶 (TA) 活性可以帮助恢复. 其他空气污染物最初延长了TL,然后缩短了TL,表明在老化之前的修复极限.
科学领域:
- 环境健康 环境健康
- 分子生物学分子生物学
- 老年学是指老年学的学科.
背景情况:
- 端粒长度 (TL) 是衰老的一个生物标志物.
- 空气污染物与衰老过程有关.
- 空气污染物对端粒的影响需要进一步研究.
研究的目的:
- 调查环境空气污染物与端粒变化之间的关联.
- 探索空气污染暴露与衰老之间的联系.
主要方法:
- 招募了26名健康的年轻人参加7项重复测量 (2019-2021年).
- 对端粒长度 (TL) 和端粒酶 (TA) 的血液样本进行分析.
- 评估了空气污染物 (O3,PM2.5,PM10,NO2,SO2,CO) 与端粒变异性之间的关联,使用线性混合效应模型,包括滞后效应.
主要成果:
- 短期臭氧 (O3) 暴露与TL负相关,并观察到恢复.
- 臭氧暴露与端粒酶 (TA) 活性有积极的关联,随着时间的推移,其活性会下降.
- 暴露在PM2.5中最初显示了与TL的积极关联,后来变得负面;没有发现与TA的显著关联.
- 其他污染物 (PM10,NO2,SO2,CO) 呈现出与PM2.5相似的模式.
结论:
- 短期暴露于臭氧会缩短TL,但TA激活有助于恢复.
- 暴露在PM2.5,PM10,NO2,SO2和CO中,最初会延长TL,然后缩短TL,这表明在老化之前有自我修复的门.
- 人体具有一定的修复空气污染物对端粒损伤的能力,但过度暴露会导致衰老.
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