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酸酸酶的儿科参考值:来自德国人口队列的分析以及人体测量和血液参数的影响
Jacqueline-Michéle Strauch1, Mandy Vogel2, Christof Meigen2
1Leipzig Research Center for Civilization Diseases - LIFE, University of Leipzig, Philipp-Rosenthal-Str. 27, 04103 Leipzig, Germany; Faculty of Medicine, University of Leipzig, Augustusplatz 10, 04109 Leipzig.
Bone
|May 28, 2023
概括
儿童的性酸酶 (AP) 参考范围因年龄和性别而异,受生长和BMI的影响. 这些发现对于解释儿科健康中的肝脏和骨代谢标志物至关重要.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 临床生物化学 临床生物化学
- 人口健康研究 人口健康研究
背景情况:
- 在儿童 (3个月18岁) 中,性酸酶 (AP) 的参考值因生长和代谢变化而与成年人不同.
- 年龄和性别显著影响AP水平,需要特定于年龄和性别的参考范围.
- 以前的文献显示了AP和身体质量指数 (BMI) 之间的有争议的关联.
研究的目的:
- 确定3个月至18岁儿童中性酸酶 (AP) 的连续,年龄和性别特定的参考百分位数.
- 调查AP水平与人类参数 (包括BMI和身高) 之间的关联.
- 在儿科群体中检查AP和肝酶 (ALAT,ASAT,GT) 之间的关系.
主要方法:
- 从3个月到18岁的3704名健康儿童 (10,272次访问) 的血清样本分析,来自LIFE儿童研究.
- 基于年龄,性别,生长和坦纳阶段的AP连续参考百分位数的计算.
- 使用线性回归模型检查AP与身高-SDS,生长速度,BMI-SDS和肝酶之间的关联.
主要成果:
- AP水平在婴儿期达到峰值,平原,然后在青春期上升 (女孩更早),然后在18岁时下降.
- 在AP-SDS和BMI-SDS之间,以及在AP-SDS和身高-SDS (在男孩中更强) 之间观察到强烈的正相关性.
- 在AP和ALAT (仅限女生) 之间,以及在AP-SDS和ASAT-SDS/GGT-SDS (两性) 之间发现了积极的关联.
结论:
- 年龄,性别和BMI是儿童AP参考范围的重要混因素.
- 这项研究证实了AP与发育过程中的生长参数 (速度,高度-SDS) 之间的强烈关联.
- 在AP与肝酶 (ALAT,ASAT,GGT) 的相关性中,特定的性别差异凸显了在儿科肝脏和骨健康中对这些标志物的仔细解释的需要.
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