患有微观结肠炎的患者患主要心血管不良事件的风险更高:一项匹配的队列研究
Anders Forss1, David Bergman2, Bjorn Roelstraete2
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Gastroenterology Unit, Department of Gastroenterology, Dermatovenereology and Rheumatology, Karolinska University Hospital, Stockholm, Sweden.
概括
微观结肠炎 (MC) 患者面临显著更高的重大心血管不良事件 (MACE) 风险,包括心脏病和中风. 这一发现凸显了微观结肠炎患者心血管监测的重要性.
科学领域:
- 胃肠病学和心脏病学
- 炎症性肠道疾病研究研究
- 公共卫生和流行病学
背景情况:
- 炎症性疾病与心血管风险增加有关.
- 微观结肠炎 (MC) 队列中主要不良心血管事件 (MACE) 的大规模数据有限.
研究的目的:
- 调查微观结肠炎与发生重大心血管不良事件 (MACE) 的风险之间的关联.
- 量化瑞典成年人被诊断患有MC的大型基于人口的队列中的心血管风险.
主要方法:
- 一个全国性的队列研究,对11,018名瑞典成年人进行了MC (1990-2017年),与48,371名参考个人进行了匹配.
- 通过组织病理学证实了MC诊断;MACE包括缺血性心脏病,充血性心力衰竭,中风和心血管死亡率.
- 考克斯的比例危险建模用于计算多变量调整的危险比率,灵敏度分析包括同胞比较.
主要成果:
- 与对照组相比,MC患者的MACE总体风险高出27% (aHR,1.27;95% CI,1.21-1.33).
- 缺血性心脏病 (aHR,1.38),充血性心力衰竭 (aHR,1.32) 和中风 (aHR,1.12) 的风险增加.
- 没有发现心血管死亡风险显著增加 (aHR,1.07).
结论:
- 微观性结肠炎与发生重大心血管不良事件的风险显著增加有关.
- 这些发现表明,在被诊断患有微观结肠炎的患者中,需要加强心血管监测.
- 每隔10年,每13名MC患者中就会出现一个新的MACE病例.
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