新的酸功能化可溶性氧化粉基非离子生物聚合物作为天然抗菌材料
Xugang Dang1, Yongmei Du2, Xuechuan Wang2
1Institute of Biomass and Function Materials & National Demonstration Centre for Experimental Light Chemistry Engineering Education, College of Bioresources Chemistry and Materials Engineering, Shaanxi University of Science and Technology, Xi'an 710021, PR China; Hubei Provincial Engineering Laboratory for Clean Production and High Value Utilization of Bio-Based Textile Materials, Wuhan Textile University, Wuhan 430200, PR China.
International journal of biological macromolecules
|May 28, 2023
概括
研究人员开发了一种新型的可溶性氧化粉基聚合物 (OCSI),具有强大的,不漏的抗菌特性. 这种环保的生物聚合物对生物医学材料,医疗器械和食品包装应用具有前景.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 抗菌剂 抗菌剂 抗菌剂
背景情况:
- 开发有效的,不漏的抗菌材料对于生物医学和食品包装应用至关重要.
- 氧化玉米粉 (OCS) 提供了一个可生物降解的平台,但需要功能化来增强性能.
- 酸 (IAA) 单体可以在聚合物骨干上移植时赋予特定的功能.
研究的目的:
- 通过将IAA移植到OCS.上来合成和描述一种新的可溶性氧化粉基非离子抗菌聚合物 (OCSI).
- 评估合成的OCSI的抗菌有效性和非可泄漏性.
- 为潜在的应用准备和评估基于OCSI的抗菌膜 (OCSI-PCL) 的特性.
主要方法:
- 通过将IAA接种到OCS上来合成OCSI.
- 使用NMR,FTIR,UV-Vis,XRD,XPS,SEM,TGA和DSC进行全面的分析表征.
- 通过磁盘扩散试验评估抗菌活性.
- 准备和评估OCSI-PCL混合膜,包括机械性能,水蒸气透性 (WVP) 和生物相容性 (CCK-8测定).
主要成果:
- 成功合成了OCSI,其替代度为0.6,具有很高的热稳定性和可溶性.
- 证明了对格拉姆阳性 (黄金葡萄球菌) 和格拉姆阴性 (大肠杆菌) 细菌具有显著的杀菌活性,抑制度低至5μg/disk.
- 开发了OCSI-PCL薄膜,具有良好的兼容性,机械性能,不漏性,低WVP,以及出色的生物相容性.
结论:
- 合成的OCSI是一种有效的,环保的,非离子抗菌生物聚合物,具有非漂水特性.
- 对于先进的应用,OCSI-PCL薄膜具有理想的特性.
- 这项研究强调了氧化粉基生物聚合物在生物医学材料,医疗设备和食品包装中的潜力.
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