使用泌尿代谢学来识别与年轻成年人心脏结构改变相关的代谢途径:非洲PREDICT研究
Wessel L du Toit1, Ruan Kruger2, Lebo F Gafane-Matemane2
1Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa.
概括
患有心血管疾病 (CVD) 风险因素的年轻人早期代谢变化与心脏结构变化有关. 这些发现强调了生活方式对心脏健康和新陈代谢从年轻时起的影响.
科学领域:
- 心血管疾病研究研究
- 代谢学 代谢学 代谢学
- 年轻人的健康年轻人的健康
背景情况:
- 年轻人患心血管疾病 (CVD) 的危险因素可能导致心脏缩和新陈代谢变化.
- 了解早期的代谢变化对于预防长期心血管事件至关重要.
研究的目的:
- 为了研究尿路代谢物和心肌结构变化之间的关联,在年轻的成年人与或没有心血管疾病风险因素.
主要方法:
- 包括1202名健康成年人 (20-30岁),分为心血管疾病风险组 (N=1036) 和对照组 (N=166).
- 使用心声学 (相对壁厚 - RWT,左心室质量指数 - LVMi) 评估心脏结构.
- 使用目标代谢学 (液体染色学-并联质谱学) 分析尿路代谢物.
主要成果:
- 与对照组相比,心血管疾病风险组表现出较高的缩血压 (BP),24小时BP和RWT.
- 在心血管疾病风险组中,RWT与肌酸和 dodecanoylcarnitine 相关;LVMi与多种氨基酸和肌酸相关.
- 在对照组中,LVMi与propionylcarnitine和butyrylcarnitine相关.
结论:
- 在患有心血管疾病风险因素的年轻人中,心脏结构变化 (LVMi,RWT) 与参与能量代谢和氧化应激的代谢物有关.
- 研究结果表明,早期代谢变化可能会影响能量生产和肌酸酶活性,伴随心脏变化.
- 生活方式和行为风险因素引发了代谢变化,这些变化与年轻成人心脏结构变化有关.
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