情绪障碍中的拉莫特里金:关于处方习惯和血液检测实践的快速调查
Margot Chouchana1, Julie Smati2, Vanessa Bloch3
1Service de pharmacie, Assistance publique des Hôpitaux de Paris, hôpital Lariboisière-Fernand-Widal, 200, rue du Faubourg-Saint-Denis, 75010 Paris, France; Inserm UMRS-1144, optimisation thérapeutique en neuropsychopharmacologie, université Paris Cité, 75006 Paris, France.
L'Encephale
|May 28, 2023
概括
法国精神病医生经常为双相情感障碍处方拉莫特林,但很少使用血水平来调整剂量. 这凸显了需要更好的治疗药物监测指南来治疗情绪障碍中的拉莫特里金.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 临床治疗学 临床治疗学
背景情况:
- 治疗药物监测 (TDM) 对于拉莫特里金在双相情感和抑郁症中并不成熟.
- 了解法国精神病学家当前的做法对于改善TDM协议至关重要.
研究的目的:
- 调查法国精神病学家对lamotrigine的处方习惯,治疗监测和剂量调整.
- 确定拉莫特里金TDM中的障碍和当前做法.
主要方法:
- 通过专家网络和医院精神病学部门向精神病学家分发了一份快速调查.
- 该调查收集了关于lamotrigine处方频率,血水平监测,剂量调整策略和感知风险的数据.
主要成果:
- 拉莫因在治疗双相情感障碍2型 (51%) 时比1型 (22%) 时更频繁地被处方.
- 皮肤毒性是15%的精神病学家的处方障碍.
- 虽然61%的人测量了lamotrigine的血水平,但只有22%的人根据结果持续调整剂量,临床反应是调整的主要驱动因素 (80%).
结论:
- 许多精神病医生监测拉莫特里金的血水平,但很少使用结果进行剂量调整.
- 在最佳血度和支持TDM在双相情感和抑郁障碍的有限数据上显著缺乏共识.
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