皮质-小脑网络的功能连接性与自闭症谱系障碍中的感觉运动行为和临床特征有关
Kathryn E Unruh1,2, James V Bartolotti3, Walker S McKinney2,4
1Life Span Institute, University of Kansas, Lawrence, KS, United States.
Cerebral cortex (New York, N.Y. : 1991)
|May 28, 2023
概括
患有自闭症谱系障碍 (ASD) 的人表现出与大脑连接性改变相关的感觉运动障碍,特别是在高强度水平时. 这些发现突显了围-小脑通路在ASD核心和并发症特征中的作用.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 自闭症研究 自闭症研究
背景情况:
- 感官运动问题在自闭症谱系障碍 (ASD) 中很常见,并且与核心症状有关.
- 在ASD中这些感觉运动障碍的神经支尚未完全理解.
- 了解这些神经系统对于解决ASD的核心和并发症特征至关重要.
研究的目的:
- 研究ASD患者视觉运动网络中的基于任务的功能连接和激活.
- 为了比较ASD和神经类型对照个体之间的视觉引导精确抓取任务期间的神经活动.
- 为了识别与感觉运动缺陷和ASD症状严重程度相关的神经标志物.
主要方法:
- 功能性磁共振成像 (fMRI) 用于检查精确抓取任务期间的大脑活动.
- 参与者包括患有自闭症症的个体 (n=19) 和年龄/性别匹配的神经类型对照 (n=18).
- 任务涉及低级和高级部队,以评估差异化的网络参与.
主要成果:
- 患有自闭症的个体表现出右主动前带状皮层与左前带状皮层 (aIPL) -右Crus I之间的功能连接性减少.
- 尾巴和小脑激活增加与控制中的感觉运动行为相关,但不是ASD,在低力下.
- 降低左边aIPL-右边Crus I连接与更大的ASD症状严重程度有关.
结论:
- 自闭症的感觉运动问题,特别是在高强度时,涉及感觉反的整合受损和错误监测的减少.
- 围-小脑连接缺陷被认为是自闭症的一个关键神经标志物.
- 研究结果表明小脑功能障碍有助于ASD的核心和并发症特征.
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