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Updated: Jul 28, 2025

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通过单链DNA调节PARP1及其亡变异活性

Waghela Deeksha1, Suman Abhishek1, Jyotsnendu Giri2

  • 1Macromolecular Structural Biology Lab, Department of Biotechnology, Indian Institute of Technology Hyderabad, Sangareddy, India.

The FEBS journal
|May 29, 2023
PubMed
概括

聚ADP-ribose) 聚合酶1 (PARP1) 通过其Zn指将单链DNA (ssDNA) 结合起来. PAR不仅释放了PARP1的ssDNA,而且还抑制了它的活性,影响了DNA修复和亡.

关键词:
修复DNA的修复DNA的修复PARP1 的第一部分.灭症 (apoptosis) 是一种死亡的过程.聚- ((ADP-ribose) 聚合酶是一种聚合酶.这就是 ssDNADNA.

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