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碳水化合物聚合物的抗病毒应用:一篇综述
Biswakanth Kar1, Deepak Pradhan1, Jitu Halder1
1School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha.
Current pharmaceutical design
|May 29, 2023
概括
碳水化合物聚合物通过改善药物输送和管理病毒感染并发症,在开发新的抗病毒治疗方面表现有前途. 本次审查强调了它们在药物开发中增强抗病毒疗法的潜力.
科学领域:
- 制药科学 制药科学
- 生物技术是生物技术.
- 材料科学 材料科学 材料科学
背景情况:
- 病毒性疾病造成重大经济损失,并由于高突变率和常规药物的局限性,造成治疗挑战.
- 目前的抗病毒策略在向细胞传递和管理次要并发症方面扎.
- 需要创新的制药方法来有效打击病毒感染.
研究的目的:
- 系统地审查各种碳水化合物聚合物在抗病毒应用中的作用.
- 分析碳水化合物聚合物的特性,影响它们的抗病毒疗效和药物输送能力.
- 探索碳水化合物聚合物的潜力,以减轻病毒引起的并发症.
主要方法:
- 在多个电子数据库中进行了系统的文献搜索.
- 包括手动搜索和高级搜索策略来识别相关研究.
- 对172篇选定的论文进行了数据提取和分析,利益相关者参与了共同撰写.
主要成果:
- 鉴定出六种关键的碳水化合物聚合物 (奇托桑,卡拉基南,阿尔吉纳特,环极,德克斯,肝素),具有显著的抗病毒潜力.
- 详细介绍了聚合物来源,分子量,电荷,组成和结构对抗病毒活性的影响.
- 证明了这些聚合物增强抗病毒药物 (如拉米丁和阿西克洛维尔) 功能的机制.
结论:
- 碳水化合物聚合物可以有效地减轻病毒感染的二次并发症,包括细菌感染和心血管疾病.
- 这些聚合物为开发用于抗病毒治疗的先进制药配方提供了一个有前途的平台.
- 这些发现为科学家和临床医生在设计基于碳水化合物聚合物的新型抗病毒药物方面提供了宝贵的见解.
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