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初级和二级进展性多发性硬化症的认知功能:一个多参数磁共振成像研究

Damiano Mistri^1,2, Laura Cacciaguerra^1,2,3, Paola Valsasina¹

¹Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.

European journal of neurology

|May 29, 2023

概括

初级渐进型和二级渐进型多发性硬化症 (MS) 患者表现出类似的认知表现. 多发性硬化症的认知衰退与明显的脑结构变化有关,而不是功能连接.

科学领域:

神经科学是一个神经科学.
放射学放射学是一门学科.
神经学神经学

背景情况:

初级渐进性多发性硬化症 (PPMS) 和次级渐进性多发性硬化症 (SPMS) 之间的认知功能差异尚未得到充分理解.
多发性硬化症 (MS) 包含各种形式,每种形式都可能对认知产生不同的影响.

研究的目的:

为了比较PPMS和SPMS患者之间的认知表现.
确定PPMS和SPMS认知功能的结构和功能磁共振成像 (MRI) 相对应物.

主要方法:

183名多发性硬化患者 (60名PPMS,123名SPMS) 和75名对照患者接受了3.0TMRI.
用神经心理测试的简短可重复电池来评估认知功能.
层次线性回归分析了MRI指标 (损伤体积,大脑体积,白质完整性,静止状态功能连接性) 与全球认知相关.

主要成果:

PPMS和SPMS组表现出可比的认知领域z分数.
在PPMS中,认知障碍与中介性lemniscus分数异质性 (FA) 和灰质体积相关.
在SPMS中,认知障碍与fornix FA和白质量 (WM) 体积相关.

结论:

在PPMS和SPMS之间,神经心理学表现类似.
这些MS亚型的认知功能障碍与独特的结构MRI异常和白质道干涉有关.
休息状态功能连接性改变没有显著地解释PPMS或SPMS的全球认知功能.

关键词:

这就是为什么MRI是MRI.执行职能执行职能是指执行职能.记忆记忆记忆记忆记忆多发性硬化症多发性硬化症

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