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Updated: Jul 28, 2025

A High-Throughput Enzyme-Coupled Activity Assay to Probe Small Molecule Interaction with the dNTPase SAMHD1
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Published on: April 16, 2021

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蛋白质氧化增加了SAMHD1通过其调节部位通过ssDNA的结合

Theresa L Simermeyer1, Stephanie Batalis1, LeAnn C Rogers1

  • 1Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Nucleic acids research
|May 29, 2023
PubMed
概括

氧化SAMHD1蛋白在S阶段增强其DNA结合,这表明它在DNA修复中的作用. 这种氧化作为一个开关,平衡其dNTPase活动与DNA结合功能.

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