出生体重,心脏代谢因素和冠心病:孟德尔的随机化研究
Shuyao Su1, Jingwen Fan1, Yongli Yang1
1Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China.
The Journal of clinical endocrinology and metabolism
|May 29, 2023
概括
低出生体重 (BW) 会增加冠心病 (CHD) 的风险,胎儿和母亲的BW都有所贡献. 像血压这样的心脏代谢因素调解了这种因果关系.
科学领域:
- 心血管流行病学心血管流行病学
- 遗传学 遗传学 是一个
- 代谢健康 代谢健康
背景情况:
- 观察性研究表明出生体重 (BW) 和冠心病 (CHD) 之间存在联系,但研究结果不一致.
- 现有的研究无法区分胎儿和母亲对BW的影响及其对心脏病风险的影响.
研究的目的:
- 调查BW和CHD之间的因果关系.
- 解开胎儿与母亲对BW相关心脏病风险的贡献.
- 量化心脏代谢因子在BW-CHD关联中的调解作用.
主要方法:
- 使用双样本的门德尔随机化 (MR) 与全基因组关联研究总结数据,用于BW (自身和后代) 和16个心脏代谢因子.
- 采用MR-Egger和逆方差加权 (IVW) 方法来估计因果关系.
- 进行了两步MR调解分析,以评估心脏代谢因素的作用.
主要成果:
- 较低的BW因果关系与心脏病风险增加有关 (IVW β = -0.30).
- 胎儿特异性和母亲特异性BW都显示出与心脏病风险具有相似的反向关联.
- 确定了五个媒介:部周长,甘油三,禁食胰岛素,腹压血压和心压血压 (SBP),介导了7.44%27.75%的效果.
结论:
- 下部BW是心脏病的因果风险因素.
- 胎儿和母亲的BW都会导致心血管疾病的风险.
- 从BW到CHD的因果途径显著受到心脏代谢因素的介导,特别是SBP和血糖因素.
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