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A Novel Method: Super-selective Adrenal Venous Sampling
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对telmisartan抑制试验的前性评估,作为猫群中原发性高固醇症的诊断工具
Maxime Kurtz1, Virginie Fabrès1,2, Renaud Dumont3
1Ecole Nationale Vétérinaire d'Alfort - CHUVA, Service de Médecine Interne, Maisons-Alfort, France.
Journal of veterinary internal medicine
|May 29, 2023
概括
口服特尔米萨坦抑制试验没有区分原发性高固醇 (PHA) 的猫与健康猫或二次性高固醇 (PHA) 的猫. 这种测试对于在猫患者中诊断PHA是不可靠的.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 以前的研究表明,telmisartan在健康的猫中抑制了阿尔多素,但在患有原发性高阿尔多素 (PHA) 的猫中没有.
- 泰尔米沙坦对患有二次性高阿尔多斯特症的猫的阿尔多斯特分泌的影响尚未完全理解.
研究的目的:
- 为了评估口服特尔米沙坦抑制试验在区分患有PHA的猫与健康猫和患有导致二次高固醇症的猫的疗效.
- 评估telmisartan对各种猫类疾病状态中的阿尔多素水平的影响.
主要方法:
- 一项前性,横截面研究涉及38只猫:5只患有PHA,16只患有慢性病 (CKD-H/CKD-NH),9只患有甲状腺功能障碍 (HTH),2只患有异常性系统性动脉高血压 (ISH) 和6只健康对照.
- 测量包括血清阿尔多斯特,和静脉血压在口服2毫克/公斤特尔米沙坦注射前和1-1.5小时后.
- 计算了阿尔多变异率 (AVR),以评估药物的抑制作用.
主要成果:
- 在PHA,CKD,HTH,ISH和健康的猫群中,没有观察到最小的阿尔多变化率 (AVR) 的显著差异 (P = .05).
- 与CKD-H和CKD-NH相比,患有PHA的猫的基础血清阿尔多素度显著更高 (经校正的P<.004).
结论:
- 单次口服2毫克/千克特尔米萨坦剂量不足以区分患有PHA的猫与健康的猫或患有二次性过高阿尔多斯特症的猫.
- 进行的telmisartan抑制试验,在研究的猫种群中缺乏PHA的诊断价值.
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