认知障碍的维持血液透析患者中改变了自发的大脑活动,以及认知功能预测模型的构建
Qing Sun1,2, Jiahui Zheng3, Yutao Zhang4
1Department of Nephrology, The Affiliated Changzhou NO.2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, China.
Renal failure
|May 29, 2023
概括
休息状态的fMRI揭示了血液透析患者的脑活动差异与认知障碍. 这些发现可能有助于诊断和评估这一群体的认知功能.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 认知障碍 (CI) 是维护血液透析 (MHD) 患者的常见并发症.
- 在MHD患者中CI的潜在大脑神经机制尚不清楚.
研究的目的:
- 研究MHD患者自发大脑活动和认知障碍之间的关系.
- 探索休息状态功能磁共振成像 (rs-fMRI) 作为MHD中CI的诊断工具的潜力.
主要方法:
- 招募了55名CI和28名健康对照的MHD患者.
- 利用rs-fMRI分析大脑活动,比较ALFF/fALFF/ReHo值.
- 用于认知功能预测的回向传播神经网络 (BPNN).
主要成果:
- 与对照组相比,患有CI的MHD患者在左侧后中枢回环和左侧下回环中呈现较低的mALFF,在右尾状核中呈现较高的mALFF.
- 改变的大脑活动指标与认知得分 (MOCA) 相关联.
- 结合血红蛋白,尿素和左后中心环mALFF的BPNN模型显示出最佳的诊断疗效 (R2 = 0.8054).
结论:
- rs-fMRI可以阐明MHD患者认知障碍的神经生理学基础.
- rs-fMRI显示为神经成像生物标志物用于诊断和评估MHD患者的CI.
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