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肠道细菌与刺激性肠综合征和慢性疲劳相关
Magdy El-Salhy1,2,3
1Department of Clinical Medicine, University of Bergen, Bergen, Norway.
便微生物种移植 (FMT) 显示出治疗生气性肠综合征 (IBS) 的潜力. 在FMT后,特定的肠道细菌变化与症状改善相关,这表明IBS和疲劳的新益生菌和饮食策略.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
背景情况:
- 刺激性肠综合征 (IBS) 的病因尚不清楚,但改变的肠道细菌和低多样性都与此有关.
- 便微生物群移植 (FMT) 正在探索其在IBS中的治疗潜力.
研究的目的:
- 审查最近关于FMT的发现,并确定可能与IBS病理生理学有关的特定肠道细菌.
- 探索FMT后的细菌变化和IBS症状严重程度之间的联系.
主要方法:
- 对研究便微生物群移植 (FMT) 在患有刺激性肠综合征 (IBS) 的患者中进行的研究的叙述性综述.
- 分析FMT后11种特定肠道细菌的丰度变化.
- 细菌丰富度的转移与IBS症状和疲劳严重程度的相关性.
主要成果:
- 增加了九种细菌 (Alistipes spp., Faecalibacterium prausnitzii, Eubacterium biforme, Holdemanella biformis, Prevotella spp., Bacteroides stercoris, Parabacteroides johnsonii, Bacteroides zoogleoformans, Lactobacillus spp.) 的丰富性. 这种细菌可以在食物中产生. 后FMT与IBS症状和疲劳相反相关.
- 降低了Streptococcus thermophilus和Coprobacillus cateniformis的丰度与症状严重程度的增加相关.
- 许多已识别的细菌产生短链脂肪酸,如丁酸盐,有利于肠道健康.
结论:
- 由FMT调节的特定肠道细菌可能在IBS病理生理学中发挥关键作用.
- 这些细菌,特别是酸盐生产者,显示出作为益生菌的承诺,用于管理IBS和疲劳.
- 饮食干预措施,如富含蛋白质和富含植物的饮食,可能会影响有益的细菌种群并改善IBS的结果.
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