提前生活和家庭风险因素 障碍 持续到成年期
David Mataix-Cols1,2, Kayoko Isomura1,2, Gustaf Brander3,4
1Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
概括
20%的儿童在成年后仍然患有滴滴障碍,儿童精神疾病和家庭精神病史是持续性滴滴障碍的关键风险因素. 需要进一步的研究来了解滴滴障碍的持续性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床流行病学 临床流行病学
背景情况:
- 许多患有滴滴障碍的儿童的情况有所改善,但成人持续性和相关因素的了解很少.
- 识别患有慢性动障碍风险的个体对于有针对性的干预至关重要.
研究的目的:
- 确定儿童时刻滴滴障碍诊断持续到成年后的比例.
- 为了确定社会人口统计学,临床和家族风险因素,使得TIC障碍的持续性.
主要方法:
- 瑞典一项全国性队列研究分析了3761名被诊断患有童年时滴答障碍的人.
- 后勤回归模型评估了变量与动障碍持久性之间的关联.
- 一个多变量模型确定了持续性的显著预测因素.
主要成果:
- 20%的儿童被诊断患有滴滴障碍的人在成年后被诊断患有慢性滴滴障碍.
- 儿童精神病并发症 (ADHD,强迫症,PDD,焦虑症) 和家庭精神病史 (提克,焦虑症) 是强有力的预测因素.
- 社会经济因素,围产期问题和自身免疫性疾病并不是显著的风险因素.
结论:
- 童年精神病并发症和家庭精神病史是滴答障碍在成年后持续存在的主要危险因素.
- 这些因素解释了约10%的动障碍持久性变异.
- 了解这些因素可以为症的临床管理和预后提供信息.
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