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孕产妇喘和后代结果的临床前模型:一个范围审查协议

Joshua L Robinson^1,2,3, Kathy L Gatford^1,4, Vicki L Clifton⁵

¹Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia.

JBI evidence synthesis

|May 29, 2023

概括

本范围审查检查了临床前母亲喘模型,以了解怀孕并发症. 它确定了母亲和后代结果的研究差距,指导未来对孕期喘的动物研究.

科学领域:

生殖生物学和免疫学
产周医学产周医学
人类疾病的动物建模.

背景情况:

在全球范围内,母性喘影响高达17%的怀孕.
与不良的周产期结局有关,如子宫前,早产和新生儿死亡.
由于人类研究的局限性,将孕产妇喘与不良结果联系在一起的机制尚不清楚.

研究的目的:

在临床前研究中系统地审查和描述母亲喘模型.
用这些模型来识别和分析母体,胎盘和后代的结果.
确定了解喘对怀孕和后代的影响的知识差距.

主要方法:

根据JBI的方法进行范围审查.
在MEDLINE,Embase和Web of Science中搜索了2022年底之前的研究.
包括非人类哺乳动物物种的体内研究.

主要成果:

提取了关于喘诱导方法,表型和特征的数据.
系统地对母体,怀孕,胎盘和后代的结果进行了目录.
总结表和核心成果列表被生成.

结论:

强调需要对母亲喘模型进行标准化报告.
确定当前关于母亲和后代结果的研究中的关键差距.
旨在指导未来临床前喘怀孕研究的开发和报告.

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