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从COVID-19致命病例的多个内分泌器官的转录变化

Anello Marcello Poma¹, Diana Bonuccelli², Elisabetta Macerola³

¹Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Via Roma, 67, 56126, Pisa, Italy. marcello.poma@med.unipi.it.

Journal of molecular medicine (Berlin, Germany)

|May 29, 2023

概括

COVID-19 改变了像上腺,胰腺和甲状腺这样的内分泌器官中的基因表达. 这项研究揭示了器官特异性基因脱调和干扰素反应,影响激素产生,并可能导致内分泌功能障碍.

科学领域:

内分泌学在内分泌学.
病毒学病毒学
分子生物学分子生物学

背景情况:

已知COVID-19后的循环激素和代谢物变化是COVID-19后的.
需要在组织层面进行基因表达研究,以了解COVID-19的内分泌功能障碍.
SARS-CoV-2 感染会影响各种器官,但它对内分泌腺体的具体影响需要详细的研究.

研究的目的:

从致命的COVID-19病例中分析五个内分泌器官内分泌特异性基因的转录水平.
为了确定由SARS-CoV-2感染引起的内分泌腺体的器官特异性转录变化.
研究COVID-19中病毒存在,干扰素反应和内分泌基因放松调节之间的关系.

主要方法:

分析了来自77名个体的116个尸体样本 (50名COVID-19病例,27名对照).
在上腺,胰腺,卵巢,甲状腺和白脂肪组织 (WAT) 中对42个内分泌特异基因和3个干扰素刺激基因 (ISG) 的转录分析.
病毒阳性/阴性COVID-19组织与未感染的对照之间的基因表达的比较.

主要成果:

感染SARS-CoV-2导致受影响组织中ISG转录水平升高.
在COVID-19病例中观察到内分泌基因 (例如,INS,TSHR,LEP) 的器官特异性放松调节.
基因转录在病毒阳性卵巢,胰腺和甲状腺中被抑制,但在上腺中增强;WAT显示ISG和瘦素转录的增强,无论病毒是否存在.

结论:

SARS-CoV-2 可以感染多个内分泌器官,引发干扰素反应.
在COVID-19中,内分泌表现可能是病毒诱导或压力诱导的转录变化的结果.
临床医生应考虑COVID-19后内分泌腺体基因表达变化的潜在内分泌功能障碍.

关键词:

在 COVID-19 疫情中,内分泌组织内分泌组织.基因表达基因表达基因表达胰岛素是一种胰岛素.勒普丁是一种激素.这就是SARS-CoV-2病毒.

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