微塑料对女性生殖系统的不良健康影响和机制:描述性综述
Vishal Afreen1, Kanza Hashmi1, Rimsha Nasir1
1Riphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore, Pakistan.
概括
聚乙烯微塑料 (PS-MPs) 通过影响卵巢,激素和引起细胞死亡,损害女性生殖. 这些塑料颗粒通过各种有毒途径破坏生殖健康.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 生殖生物学 生殖生物学
背景情况:
- 小于5毫米的微塑料 (MP) 是普遍存在的环境污染物.
- 包括聚钢 (PS-MP) 在内的MP存在于各种形式,并进入生态系统,对野生动物构成风险.
- 以前的研究表明,MPs可以在动物中引起生殖毒性.
研究的目的:
- 审查聚烯微塑料 (PS-MPs) 对女性生殖系统的不良影响.
- 阐明通过PS-MPs诱导生殖毒性的特定机制和途径.
主要方法:
- 对调查PS-MP和女性生殖健康的研究进行文献综述.
- 对详细介绍PS-MPs暴露对细胞和分子影响的研究进行分析.
- 检查对内分泌干扰和器官特异性毒性的影响.
主要成果:
- 暴露于PS-MPs与卵巢较大,卵泡较少,胚胎产量减少以及小鼠怀孕率较低有关.
- 观察到荷尔蒙失衡和氧化应激,影响生育能力.
- 通过NLRP3/caspase和Wnt途径在颗粒细胞中的细胞死亡 (亡,烧亡).
- 由于TL4/NOX2激活,子宫纤维化和子宫内膜变薄.
- 对卵巢功能,卵细胞成熟和质量产生负面影响.
- 在海洋动物中,下丘脑 - 垂体 - 淋巴腺轴的破坏,影响生殖和后代.
- 降低生育能力和生殖系细胞亡.
结论:
- 聚乙烯微塑料对各种物种的女性生殖健康构成重大威胁.
- 多种细胞和分子通路与PS-MP诱导的生殖毒性有关.
- 进一步的研究至关重要,以了解微塑料污染带来的生殖风险的全部范围.
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