通过准VPAC受体来诊断口腔癌:初步报告
Rajendra Nerli1, Mahesh Kalloli2, Shadab Rangrez1
1Department of Urology, JN Medical College, KLE Academy of Higher Education & Research (Deemed-to-be-University), JNMC Campus, Belagavi, India.
Asian Pacific journal of cancer prevention : APJCP
|May 29, 2023
概括
检测口腔癌是可行的使用VPAC (血管活性肠道/垂体腺酸环酶激活) 受体向唾液中的恶性细胞. 这种非侵入性方法在早期检测口腔癌方面具有很高的准确性.
科学领域:
- 在瘤学瘤学.
- 细胞病理学 细胞病理学
- 分子生物学分子生物学
背景情况:
- 口腔癌是一个重大的全球健康挑战.
- 皮细胞学有助于区分前恶性和恶性口腔病变.
- 基因组VPAC受体在口腔癌细胞上表达.
研究的目的:
- 评估针对VPAC受体进行口腔癌检测的有效性.
- 评估使用脱皮细胞学用于口腔癌诊断的可行性.
- 将VPAC受体检测与标准细胞学方法进行比较.
主要方法:
- 使用细胞学刷收集口腔病变样本.
- 通过标准PAP染色和VPAC受体光显微镜分析样品.
- 检查了VPAC受体表达的口腔 gargle 样本中的恶性细胞.
主要成果:
- 包括60名患有口腔病变的患者;30名被诊断患有状细胞癌.
- 在刷细胞学和口腔声中的VPAC受体阳性比PAP染色更敏感.
- 准确率:PAP染色 (86.67%),刷毛VPAC (91.67%),嘴VPAC (95%). 这三种方法的准确率是:
结论:
- 唾液中的恶性细胞可以通过准VPAC受体来识别.
- 这种VPAC受体向方法简单,非侵入性,可靠.
- 这项研究支持VPAC受体分析作为口腔癌检测的有希望的工具.
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