雌激素,孕和雄激素受体在原发性和复发性形唾液腺瘤中
Bassel Tarakji1, Faisal Mehsen Alali1
1Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia.
Asian Pacific journal of cancer prevention : APJCP
|May 29, 2023
概括
雄激素受体可能在形腺瘤 (PA) 和复发性形腺瘤 (RPA) 中发挥作用. 没有发现雌激素和孕激素受体参与了这些唾液腺瘤的发展.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 内分泌学 在内分泌学.
背景情况:
- 形腺瘤 (PA) 是最常见的唾液腺瘤.
- 复发性形腺瘤 (RPA) 可能在初始治疗后出现.
- 在PA和RPA中的荷尔蒙受体表达尚未得到充分理解.
研究的目的:
- 为了研究雌激素受体 (ER),孕激素受体 (PR) 和雄激素受体 (AR) 在原发性和复发性多形腺瘤中的免疫组织化学表达.
- 确定这些受体在PA和RPA的病变发生过程中的潜在作用.
主要方法:
- 对30种原发性多样性腺瘤 (PA) 和15种复发性多样性腺瘤 (RPA) 的回顾性分析.
- 对ER,PR和AR进行免疫组织化学染色.
- 两个独立观察者对受体表达的半定量评估.
- 描述性统计和数据分析的比例频率.
主要成果:
- 在40%的PA和46%的RPA病例中检测到雄激素受体 (AR) 表达.
- 在PA和RPA中,雌激素受体 (ER) 和孕激素受体 (PR) 表达是负的.
- 在原发性和复发性瘤之间没有观察到AR表达的显著差异.
结论:
- 雄激素受体可能参与形腺瘤的发展和复发.
- 雌激素和孕激素受体似乎没有在形腺瘤的发病或其复发中发挥作用.
相关概念视频
Salivary Glands and Saliva
776
The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...
776
Secondary Messengers in Hormone Action
2.4K
Water-soluble hormones cannot cross the plasma membrane, so they rely on protein receptors that span the membrane to trigger intracellular signaling pathways. These pathways then activate second messengers inside the cell, including cAMP or calcium ions.
Many hormones bind to transmembrane G protein-coupled receptors that connect to regulatory G proteins. These G proteins can then activate enzymes such as adenylyl cyclase or phospholipase C. Adenylyl cyclase converts ATP to cAMP, activating...
Many hormones bind to transmembrane G protein-coupled receptors that connect to regulatory G proteins. These G proteins can then activate enzymes such as adenylyl cyclase or phospholipase C. Adenylyl cyclase converts ATP to cAMP, activating...
2.4K
Exocrine Glands: Types of Secretions
2.4K
Exocrine glands produce and release a variety of glandular products. Exocrine glands can be classified into serous, mucous, or mixed types based on their secretory products.
Serous glands produce watery secretions rich in digestive enzymes and proteins. The constituent cells of the serous gland have centrally located nuclei and eosinophilic secretory granules in the cytoplasm. The parotid gland is an example of a serous gland. It secretes saliva, which contains enzymes, such as lipases and...
Serous glands produce watery secretions rich in digestive enzymes and proteins. The constituent cells of the serous gland have centrally located nuclei and eosinophilic secretory granules in the cytoplasm. The parotid gland is an example of a serous gland. It secretes saliva, which contains enzymes, such as lipases and...
2.4K


