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诺本索摩衍生型 σ2R/TMEM97调制剂的立体异构体的结构-亲和关系

Yan Lu1, Qi Gu1, Stephen F Martin1

  • 1Department of Chemistry, The University of Texas at Austin, Austin, TX, 78712, United States.

European journal of medicinal chemistry
|May 29, 2023
PubMed
概括

研究人员探索了具有B-norbenzomorphan核心的新型西格玛2受体 (σ2R) 配体. 该 (1S,5R) -enantiomers显示较高的亲和力 σ2R/TMEM97,与一些化合物表现出良好的选择性超过 σ1R.

关键词:
结合的亲和关系和选择性.计算式对接方式西格玛受体的受体是什么综合合成 综合合成

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