短期与长期抗生素治疗呼吸机相关肺炎:随机对照试验的系统审查和元分析
Huzaifa Ahmad Cheema1, Aayat Ellahi2, Hassan Ul Hussain3
1Department of Chest Medicine, King Edward Medical University, Lahore, Pakistan.
Journal of critical care
|May 29, 2023
概括
短期抗生素治疗非发酵性格拉姆阴性细菌呼吸器相关肺炎 (NF-GNB VAP) 可能会增加肺炎复发的风险. 然而,与长期疗程相比,死亡率没有显著差异.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
背景情况:
- 目前的指导方针建议短期使用抗生素治疗非发酵格拉姆阴性菌根 (NF-GNB) 引起的呼吸机相关肺炎 (VAP).
- 这种方法可能与肺炎复发的风险更高有关.
- 进行了一项元分析,以比较VAP的短期和长期抗生素治疗方案.
结论:
- 低质量的证据表明,与长期疗程相比,NF-GNB VAP的短期抗生素疗程与较高的肺炎复发率有关,而不会影响死亡率.
- 为了得出最终结论,需要进行更大规模的盲目的RCT.
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