酸性多糖的结构和药物输送关系:一篇综述
Riya Banerjee1, K Jayaram Kumar1, John F Kennedy2
1Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, 835215, Jharkhand, India.
International journal of biological macromolecules
|May 29, 2023
概括
酸性多糖因其独特的特性而显示出药物输送的前景. 本综述探讨了它们的结构活动,修改和组合,以增强医疗应用.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 制药科学 制药科学
背景情况:
- 多糖因其卓越的物理,化学和生物特性而越来越多地被用于医疗管理.
- 酸性多糖化合物,包括pectin,xanthan gum,carrageenan,alginate和glycosaminoglycan,是天然的聚合物,具有用于药物递送系统的卡基组.
- 目前的文献往往缺乏关于多糖在药物输送中的结构相互作用的详细讨论,这限制了它们的应用范围.
研究的目的:
- 为了阐明酸性多糖在药物输送中的结构-活性关系.
- 审查修改过程及其对多糖的功能的影响.
- 探索不同酸性多糖化合物结合用于增强药物输送应用的效果.
主要方法:
- 文献综述,重点关注用于药物输送中的酸性多糖.
- 对所选多糖的结构性质和修饰的分析.
- 综合关于用于药物输送的联合多糖体系统的信息.
主要成果:
- 详细检查了pectin,xanthan,carrageenan,alginate和glycosaminoglycan的结构特征.
- 确定提高药物输送能力的关键修改.
- 了解各种酸性多糖化合物的组合时产生的协同效应.
结论:
- 酸性多糖为先进的药物输送系统提供了显著的潜力.
- 了解结构-活动相关性和修改效应对于优化它们的使用至关重要.
- 对组合多糖系统的进一步研究可以解锁新的治疗应用.
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