雌激素-铁轴在不同年龄的孕妇纯种西班牙马匹的适应性反应
Katiuska Satué1, Esterina Fazio2, Deborah La Fauci2
1Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, CEU-Cardenal Herrera University, Valencia, Spain.
Journal of equine veterinary science
|May 29, 2023
概括
孕母马的铁稳态随着年龄的增长而变化,年轻的马通过雌激素和肝素激素显示出高效的铁调节. 年长的母马表现出反向的机制,表明随着年龄的增长,铁代谢效率下降.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 生殖内分泌学 生殖内分泌学
- 矿物质的新陈代谢.
背景情况:
- 铁 (Fe) 稳态对于生理功能至关重要,雌激素影响成熟动物的铁吸收和调动.
- 已知雌激素介导的肝素 (Hpc) 调节会影响Fe的可用性,以满足母亲和胎儿的需求.
- 马匹怀孕期间Fe,Hpc和雌激素调节的特定与年龄相关的变化仍然在很大程度上没有特征.
研究的目的:
- 为了研究血清Fe,Ferritin (Ferr),Hpc和雌激素 (雌激素[E1],雌激醇-17β[E2]) 度之间的相互关系,在怀孕的马匹中.
- 评估年龄增长如何影响西班牙纯种马匹的这些参数.
主要方法:
- 从40只怀孕的西班牙纯种马匹收集了血液样本,分别来自四个年龄组 (4-6,7-9,10-12,>12岁).
- 测量了血清中的Fe,Ferr,Hpc,E1和E2度.测量了血清中的Fe,Ferr,Hpc,E1和E2度.
- 进行了统计分析,以比较群体并评估相关性.
主要成果:
- 年轻的母马 (4-6岁和7-9岁) 与老年群体相比,具有更高的Fe和Fer度.
- 较老的母马 (>12岁) 显示Hpc增加和E1水平降低.
- 雌激素-17β (E2) 水平在7-9岁及以上的母马中高于最年轻的群体,但在12岁以上的群体中相比于7-9岁的群体下降. Fe和Ferr与Hpc呈负相关性,而E2与Hpc呈正相关性.
结论:
- 一个独特的"雌激素-铁轴"似乎通过hpc抑制,在年轻的孕母马中促进有效的铁状况.
- 这些调节机制在老年马匹中被逆转,这表明随着年龄的增长,铁代谢受损.
- 需要进一步的研究来充分阐明复杂的荷尔蒙和代谢相互作用,这些相互作用决定了马类繁殖中的铁状况.
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