在怀孕期间接触双和甲酸盐,以及儿童肺功能和喘的发展. "R世代研究"是一项研究
Tarik Karramass1, Chalana Sol2, Kurunthachalam Kannan3
1The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Pediatrics, Division of Respiratory Medicine and Allergology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
胎儿接触双醇和酸盐没有显示出与儿童呼吸系统健康的强烈联系. 双S (BPS) 显示了与肺功能和喘风险的一些关联,但需要更多的研究.
科学领域:
- 环境健康 环境健康
- 儿童呼吸系统健康问题
- 内分泌干扰 干扰内分泌系统
背景情况:
- 胎儿接触双和酸盐可能会对儿童呼吸系统和免疫系统发育产生负面影响.
- 儿童的不良呼吸系统健康结果与产前接触这些化学物质有关.
研究的目的:
- 调查胎儿暴露于双醇和酸盐与肺功能之间的关联.
- 为了检查胎儿暴露于双醇和酸盐和13岁时喘发育之间的关系.
主要方法:
- 一项前性队列研究,涉及1020名儿童.
- 在怀孕期间采集的母亲尿液样本,以测量双和甲酸盐度.
- 通过螺旋计评估肺功能,通过问卷诊断诊断13岁的喘.
主要成果:
- 怀孕期间母亲尿液中双和酸盐水平的平均值与儿童肺功能或喘无关.
- 第二季度暴露于单异布甲酸与更高的FEV1/FVC比率有关.
- 双S (BPS) 显示出与肺功能减弱和喘风险改变的一些关联,特别是以性别依赖的方式,但在多次测试纠正后,这些并没有始终达到统计学意义.
结论:
- 产前暴露于双和甲酸盐,平均或按季度,并没有表明与13岁儿童的肺功能或喘有很强的关联.
- 作为Bisphenol A (BPA) 的替代品的Bisphenol S (BPS) 表明了与肺功能受损和喘风险改变的潜在联系,这需要在当前人群中进行进一步的研究.
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