在儿童中,多环芳内部暴露和尿度与甲状腺体积的关联
Zhiyu Yang1, Shouyi Chen2, Si Zhou2
1Guangzhou Center for Disease Control and Prevention, Guangzhou, 510440, China; Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, 510632, China.
Environmental pollution (Barking, Essex : 1987)
|May 29, 2023
概括
对多环芳 (PAH) 的暴露与儿童甲状腺体体积增加有关. 水平部分调解了这种关联,这表明环境污染物和甲状腺健康之间存在复杂的关系.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 儿科健康 儿科健康
背景情况:
- 甲状腺体积是评估甲状腺结节的一个关键因素.
- 多环芳 (PAHs) 是已知的内分泌干扰剂,但它们与甲状腺体积的联系还未得到充分研究.
- 评估内部暴露于PAH及其对儿童甲状腺体体积的影响至关重要.
研究的目的:
- 调查多环芳 (PAHs) 的内部暴露与学龄儿童甲状腺体体积之间的关联.
- 检查尿液度在PAHs和甲状腺体积之间的关系中的作用.
- 评估PAHs对儿童群体甲状腺大小的潜在内分泌干扰作用.
主要方法:
- 一项涉及中国广州590名学龄儿童的横截面研究.
- 测量尿液中氧化多环芳 (OH-PAH) 和尿液中的度.
- 使用超声波和使用多变量线性回归和贝叶斯核机器回归模型的统计分析来评估甲状腺体体积.
主要成果:
- 尿中 ΣOH-PAHs 与甲状腺体积显著正相关 (3.88%的变化,每单位增加日志转换的 ΣOH-PAHs).
- 贝叶斯核机器回归证实了尿中增加的SOH-PAHs对甲状腺体体积的积极联合作用.
- 尿中SOH-PAHs与尿中有显著的联系,介导了OH-PAHs与甲状腺体体积之间的关系的15.2%.
结论:
- 对PAHs的内部暴露与儿童甲状腺体积增加有关.
- 尿液中的度在PAH暴露和甲状腺体积之间的关系中起着调解作用.
- 研究结果强调了环境污染物对儿童甲状腺发育和功能的潜在影响.
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