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Updated: Jul 28, 2025

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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对于 (较低) 吗啡剂量策略,非线性血脑屏障的运输是否重要?

Berfin Gülave1, Divakar Budda1, M A A Saleh1

  • 1Division of Systems Pharmacology and Pharmacy, Leiden Academic Center for Drug Research, Leiden University, Leiden 2333 CC, the Netherlands.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
|May 29, 2023
PubMed
概括

跨越血脑屏障 (BBB) 的非线性吗啡运输会影响大脑的暴露和波动,特别是在较低剂量时. 剂量策略显著影响大脑细胞外流体 (大脑ECF) 中的吗啡药业动力学.

关键词:
血液-大脑屏障是什么?在LeiCNS-PK3.0中使用.吗啡是一种吗啡.非线性 非线性

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