1p/19q代分离在扩散性低度质瘤瘤预后中的作用
Pietro Familiari1, Pierfrancesco Lapolla2,3, Veronica Picotti1,4
1Department of Human Neurosciences, Division of Neurosurgery, Policlinico Umberto I University Hospital, Sapienza University of Rome, Rome, Italy.
Anticancer research
|May 29, 2023
概括
在扩散性低度质瘤 (DLGGs) 中的1p/19q共删除显著改善了存活率,并延迟了恶性转变. 切除程度 (EOR) 是一个关键的预后因素,但当存在1p/19q共删除时,其影响更大.
科学领域:
- 神经瘤学神经瘤学
- 分子诊断学 分子诊断学
- 手术瘤学手术瘤学
背景情况:
- 扩散性低度质瘤 (DLGGs) 是根据2021年世卫组织中枢神经系统瘤分类的IDH突变来定义的.
- 切除程度 (EOR) 影响生存,但其与1p/19q共删除的独立性仍在争论中.
研究的目的:
- 追溯分析1p/19q共删除和EOR对DLGG患者结局的影响.
- 为了将瘤遗传学和手术程度与生存和进展相关联.
主要方法:
- 对66名接受手术的DLGG患者 (2008-2018) 的回顾性分析.
- 患者被分类为扩散性星细胞瘤 (DA,没有1p/19q共删除) 或寡合质瘤 (OG,1p/19q共删除).
- 根据切除程度的子组:分总 (STR) 和总总 (GTR). 测量结果:整体存活率 (OS),无进展存活率 (PFS),恶性转变时间 (TMT).
主要成果:
- 与扩散性星细胞瘤 (DA) 患者相比,具有1p/19q共删除的Oligodendroglioma (OG) 患者表现出较长的OS,PFS和TMT.
- 在这两组中,总体切除 (GTR) 总体上比亚总切除 (STR) 结果更好.
- EOR的预测值在具有1p/19q共删除的OG患者中更为明显.
结论:
- 1p/19q共删除是DLGGs显著的积极预后标志物,与延长存活时间和延迟恶性转变有关.
- 手术切除 (EOR) 的程度仍然是DLGG患者的关键预后因素.
- 1p/19q共删除状态和EOR之间的相互作用显著影响患者的结果.
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