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Updated: Jul 28, 2025

Characterization of Glycoproteins with the Immunoglobulin Fold by X-Ray Crystallography and Biophysical Techniques
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Published on: July 5, 2018

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通过冷-EMEM对双特异交叉双变抗体结构的结构洞察力

David Fernandez-Martinez1,2,3, Mark D Tully1, Gordon Leonard1

  • 1European Synchrotron Radiation Facility, 71 Avenue des Martyrs, 38042, Grenoble, France.

Scientific reports
|May 29, 2023
PubMed
概括

研究人员使用冷EM描述了针对IL-13的双特异抗体的结构. 一种新的标记策略使结构确定成为可能,揭示了1:1结合性静脉测量,并有助于开发用于癌症免疫治疗的多特异性抗体.

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Antibody Structure01:10

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
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Antibody Structure and Classes

Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
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Cross-reactivity

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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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