孕前和妊娠高血压的多基因预测
Michael C Honigberg1,2,3, Buu Truong4,5, Raiyan R Khan6
1Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. mhonigberg@mgh.harvard.edu.
Nature medicine
|May 29, 2023
概括
研究人员确定了18个与妊娠前和妊娠高血压相关的基因位置,改善了预测,并可能指导这些常见妊娠并发症的预防策略.
科学领域:
- 遗传学 遗传学 是一个
- 产科 产科 产科 产科 产科
- 基因组医学是基因组医学.
背景情况:
- 孕前和孕期高血压是严重的妊娠并发症,预测和预防工具有限.
- 与这些妊娠高血压疾病相关的是不良的孕产妇和婴儿后果.
结论:
- 鉴定到的基因位置为怀孕的高血压疾病提供了机械的见解.
- 多基因风险得分可以提高怀孕风险分层,并重新分类适合预防性治疗,如低剂量阿司匹林.
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