血栓性基因多态性和重复性流产:系统性审查和元分析
Yuanjia Wen1, Haodong He1, Kai Zhao2
1Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Journal of assisted reproduction and genetics
|May 29, 2023
概括
这一元分析显示,包括MTHFR C677T和PAI-1 4G/5G在内的特定遗传性血栓,与重复性妊娠损失 (RPL) 有显著的关联. 这些发现可能有助于确定RPL的原因并指导向治疗.
科学领域:
- 生殖医学 生殖医学
- 遗传学 是一个遗传学.
- 血栓友爱症 (Thrombophilia) 是一种发生血栓友爱症的疾病.
背景情况:
- 复发性流产 (RPL) 影响到1-4%的女性,超过50%的病例仍然无法解释.
- 人们越来越多地认识到遗传性血栓塞病是导致无法解释的RPL的潜在原因.
研究的目的:
- 调查常见的血栓友多态和RPL之间的关联.
- 进行文献综述和元分析来探索这些关系.
主要方法:
- 在PubMed,Embase,Cochrane和Web of Science数据库 (1997-2022) 中进行全面的搜索.
- 包括观察性研究,并使用固定或随机效应模型进行元分析.
- 评估出版偏差和研究质量,分别使用埃格尔测试和纽卡斯尔太华尺度.
主要成果:
- 分析了124篇文章,涉及17278名RPL患者和16021名对照.
- 在RPL和MTHFR C677T,MTHFR A1298C,PAI-1 4G/5G,血管酶转化酶I/D,XIII因子V34L和β-纤维素-455G/A多态体之间发现了显著的关联.
- 优势和衰退遗传模型的几率比率 (ORs) 和95%置信区间 (CI) 被计算出来.
结论:
- 鉴定出血栓性多态体是评估RPL风险的潜在临床标志物.
- 这些标记物可以帮助识别无法解释的RPL的原因,从而有可能实现个性化治疗策略.
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