在第一民族人群中,针对COVID-19疫苗的强大和原型免疫反应受到伴随性疾病的影响
Wuji Zhang1, Lukasz Kedzierski1,2, Brendon Y Chua1
1Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
Nature immunology
|May 29, 2023
概括
澳大利亚原住民对COVID-19疫苗接种表现出强烈的免疫反应,产生抗体和T细胞. 慢性健康状况,而不是种族,与免疫反应的减少有关.
科学领域:
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
- 遗传学 是一个遗传学.
背景情况:
- 包括澳大利亚原住民在内的土著人口面临更高的严重COVID-19风险.
- 了解这些群体的疫苗诱导免疫力对于公共卫生战略至关重要.
研究的目的:
- 评估COVID-19 BNT162b2疫苗接种在澳大利亚原住民中引起免疫反应的有效性.
- 确定影响免疫反应的因素,如年龄,体重指数和慢性健康状况.
主要方法:
- 分析中和抗体,受体结合域 (RBD) 抗体,SARS-CoV-2尖端特异性B细胞和疫苗接种后的CD4+/CD8+T细胞反应.
- 免疫标记与人口和临床因素的相关性分析.
- 检查IgG糖化和介质素-18水平与免疫反应和并发病相关的情况.
主要成果:
- 澳大利亚第一民族人群表现出有效的免疫反应,包括中和抗体和T细胞激活.
- RBD IgG抗体标位与人体质量指数正相关,与年龄负相关.
- 已接种疫苗的患有慢性疾病 (糖尿病,病) 的个体观察到抗体和B细胞反应的减少,与IgG糖化变化和高interleukin-18.8相关.
结论:
- 接种COVID-19 BNT162b2疫苗会在澳大利亚原住民群体中产生强大的免疫反应.
- 伴随性疾病,而不是种族,与免疫反应减弱有关,突出显示慢性疾病对疫苗疗效的影响.
- 调查结果强调了疫苗接种对原住民人口的重要性,这些原住民不成比例地受到慢性疾病的影响.
相关概念视频
Factors Affecting the Risk of Infection
12.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.1K
Factors Affecting Illness
4.3K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
4.3K
Development of Immunocompetence
369
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
369
Immunodeficiency Diseases
1.0K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
1.0K
Vaccinations
44.9K
Overview
44.9K
Immune Response Against Viral Pathogens
837
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
837


